DSIP
Delta Sleep Inducing Peptide
DSIP (Delta Sleep Inducing Peptide) is a naturally occurring 10-amino-acid peptide found in the body, studied for its role in regulating deep sleep, nervous system recovery, and neuroendocrine balance.
Chemical identity
- Sequence
- WAGGDASGE
- Molecular formula
- C35H48N10O15
- Molecular weight
- 848.8 g/mol
- CAS no.
- 62568-57-4
Purity (HPLC) measures the absence of related impurities; it is distinct from net peptide content, since salts and counter-ions (acetate, TFA) count toward the vial mass. Account for this when computing the real concentration at reconstitution.
Potential benefits
Sleep quality
Supports deep, restorative sleep (delta stage).
Cognitive recovery
Contributes to mental clarity and memory consolidation.
Nervous fatigue
Helps reduce mental fatigue and nervous load.
Stress management
Promotes relaxation and helps regulate stress responses.
Overall recovery
Supports physical and mental recovery.
Mechanism of action
- A naturally occurring peptide in the body, involved in numerous physiological processes.
- Promotes access to deep sleep (delta stage), the most restorative phase for the body and brain.
- Works by supporting the body's natural mechanisms — it is not a sleeping pill.
- Contributes to neuroendocrine homeostasis and nervous system balance.
Historical milestones
Research milestones, clinical trials and regulatory steps.
- 1963
A sleep factor hypothesized
In Basel, Monnier and Schoenenberger observe that cerebral venous blood from a sleeping rabbit induces delta EEG activity in an awake animal.
- 1977
Isolation and sequencing
The team isolates, characterizes and synthesizes the delta sleep-inducing peptide (DSIP), a nonapeptide of sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu.
- 1980s
Multifunctional studies
Numerous studies explore effects beyond sleep, including modulation of stress, pain and neuroendocrine rhythms.
- 2026
Research status
DSIP remains an experimental peptide, with no approved drug and no clear consensus on its physiological role.
Evolution over time
Initial improvement in falling asleep and sleep depth.
Noticeable improvement in sleep quality and nervous recovery.
Effects continue to improve with appropriate use.
Dosages & protocol
Reference dosages
6 wk + 3 off
30 to 60 min before bedtime
Very short plasma half-life (on the order of minutes, ~15-25 min) due to rapid enzymatic degradation; effects on sleep persist well beyond that.
Profiles studied in the literature
- People subject to high daily stress
- Intense intellectual work or studies
- Non-restorative sleep
- Athletes in a recovery period
- Jet lag & disrupted rhythms
- People seeking better nervous balance
Usage tips
- Establish a consistent sleep routine.
- Limit screens and blue light in the evening.
- Avoid caffeine and stimulants late in the day.
- Favor a cool, dark, and quiet environment.
- Combine DSIP with good lifestyle habits for optimal results.
Good to know / effects to watch
- Studies report possible daytime drowsiness or a groggy feeling (morning "hangover") after administration.
- Mild headaches and transient mood changes may be observed.
- Poorly characterized neuro-hormonal effects are described, with human data remaining limited and not well consolidated.
- Local reactions at the injection site (redness, discomfort) when the subcutaneous route is used.
- Known hypersensitivity to the compound or any of its excipients: to be avoided. Consult a healthcare professional if in doubt.
Storage
- Before reconstitution: store the lyophilized powder refrigerated (2-8 °C) or frozen (-20 °C), protected from light and moisture.
- After reconstitution: keep refrigerated (2-8 °C) and use within ~28 days.
- Do not freeze the reconstituted solution; protect it from light and do not leave it at room temperature.
Contraindications
- Pregnancy and breastfeeding: avoid as a precaution (no human data).
- Combination with sedatives, hypnotics, anxiolytics or alcohol: caution (risk of additive drowsiness).
- Unstable neurological or psychiatric conditions: seek medical advice before use.
- Known hypersensitivity to the compound or an excipient; not advised in children.
- Experimental research compound, not approved as a medicine (FDA/EMA).
Possible synergistic combinations
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At low doses if needed, depending on individual sensitivity.
Sources & references
Links to external sources (scientific databases, trial registries, authorities). RAL Peptides is not responsible for their content.
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⚠ For research use only. NOT intended for use on humans or animals. The values shown are indicative and for informational purposes ; each person reacts differently. This guide does not replace medical advice — consult a healthcare professional if in doubt.